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Paws, Purrs & Exotics Animal Hospital

Amoxicillin-Clavulanic Acid

What is amoxicillin-clavulanic acid?

Amoxicillin-clavulanic acid, also known as amoxicillin and clavulanate potassium (brand name Clavamox®), is a synthetic, penicillin-type antibiotic used to treat infections caused by certain types of bacteria (gram-positive and gram-negative). It is used to treat skin infections, soft tissue infections, and periodontal (gum) disease. Clavulanic acid has been added to the amoxicillin to protect the antibiotic from certain enzymes that may destroy the amoxicillin before it can kill the bacteria.

It is used “off label” or “extra-label” to treat urinary tract infections and some other infections in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet amoxicillin-clavulanic acid?

Amoxicillin-clavulanic acid comes in a tablet and liquid suspension form.

This medication will take effect quickly, in about 1 to 2 hours, but outwardly, effects may take a few days to be recognized.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from amoxicillin-clavulanic acid?

Amoxicillin-clavulanic acid may cause the following side effects:

If stomach upset occurs, try giving the medication with food. These signs should go away during treatment; if they continue, contact your veterinarian.

The following reactions are rare, but if they occur, contact your veterinarian immediately:

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Are there any drug interactions I should be aware of?

Certain medications should be USED WITH CAUTION when given with amoxicillin-clavulanic acid, including but not limited to:

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is there any monitoring that needs to be done with this medication?

How do I store amoxicillin-clavulanic acid?

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jan 26, 2024.

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